ea0035p586 | Endocrine tumours and neoplasia | ECE2014
Dworakowska Dorota
, Dudka Dorota
, Weistman Gregory
, King Peter
, Diaz-Cano Salvador
, Korbonits Marta
, Grossman Ashley B
, Aylwin Simon
, Schulte Klaus-Martin
, Sworczak Krzysztof
, Ng Tony
Introduction: Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis and limited therapeutic options. Mitotane is considered as a first-line therapy but only 30% of the patients showing an objective tumour response.Erlotinib and gefitinib (tyrosine kinase inhibitors TKI) inhibit the epidermal growth factor receptor (EGFR), which is highly expressed and occasionally mutated in various cancers. EGFR expression was found to be a good ...